概述
Mitral valve prolapse (MVP) is the most common valvular heart disease, affecting about 2–3% of the general population and is well characterized by echocardiography. While the outcome in MVP is mostly benign in the absence of mitral regurgitation (MR) and its left-ventricular (LV) consequences, a small yet poorly defined subset of individuals remain at higher risk of malignant ventricular arrhythmias (VAs) and sudden cardiac death (SCD). This link between MVP and SCD is reported with an annual incidence <1% in unselected individuals with MVP. However, at autopsy, the prevalence of MVP among young patients with sudden arrhythmic death is reported between 4% to up to 7%. Due to the low event-rate and the lack of very large cohorts, assessing the precise incidence of SCD in MVP in general and in specific subsets of patients remains challenging.