The history is the most important tool to determine whether a
patient has had anaphylaxis and the cause of the episode (C).
A thorough differential diagnosis should be considered, and other
conditions should be ruled out (C). Laboratory tests can be helpful
to confirm a diagnosis of anaphylaxis or rule out other causes.
Proper timing of such tests (eg, serum tryptase) is essential (B). In
the management of a patient with a previous episode of anaphylaxis,
education is necessary.
