概述
The first Scottish Intercollegiate Guidelines Network (SIGN) guideline on antibiotic prophylaxisin surgery (SIGN 45)1 was published in July 2000 to provide evidence based recommendations toreduce inappropriate prophylactic antibiotic prescribing. Evidence from the Scottish Surveillanceof Healthcare Associated Infection Programme (SSHAIP) on surgical site infection indicates ahigh compliance with the guideline’s recommendations.2 The original guideline addressed riskfactors for surgical site infection (SSI), benefits and risks of antibiotic prophylaxis, indications forsurgical antibiotic prophylaxis as well as recommendations on administration of intravenousprophylactic antibodies.